![]() Mitochondria are classically known as the “powerhouses of the cell” for their central role in respiratory adenosine triphosphate synthesis, and attention is given to mitochondrial electron transport, in both the context of mitochondrial respiration and mitochondrial steroid metabolism. We then discuss the cellular biology of steroidogenesis, placing special emphasis on the mitochondria. In this paper, we discuss this functionalization, beginning with the tissue zonation of the adrenal cortex and how this impacts steroidogenic output. ![]() It possesses a great degree of specialized compartmentalization at multiple hierarchical levels, ranging from the tissue down to the molecular levels. ![]() The adrenal cortex is critical for physiological function as the central site of glucocorticoid and mineralocorticoid synthesis. ![]()
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